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testosterone enanthate side effects

testosterone enanthate side effects

Took – a combined preparation, which comprises: a non-narcotic analgesic metamizol sodium (analgin) myotropic antispasmodic pitofenone hydrochloride and M-holinoblokiruschee means fenpiveriniya bromide. testosterone enanthate side effects has analgesic, antipyretic and weak anti-inflammatory action. Pitofenone hydrochloride, like papaverine, has a direct effect on myotropic smooth muscles of internal organs and causes it to relax. Fenpiveriniya bromide by M-anticholinergic action exerts additional antispasmodic action on smooth muscle.

INDICATIONS
Pain (mild to moderate) with spasms of smooth muscles of internal organs: renal colic, spasms of the ureter and bladder, biliary colic, intestinal colic, biliary dyskinesia, postcholecystectomical syndrome, tuberculosis.
For short-term symptomatic treatment: arthralgia, neuralgia , myalgia, sciatica.
as adjuvant: pain after surgical and diagnostic procedures.

CONTRAINDICATIONS
Hypersensitivity to pyrazolone derivative (phenylbutazone), and other ingredients; inhibition of bone marrow hematopoiesis; stable and unstable angina; chronic heart failure in the stage of decompensation; expressed human liver and / or kidney problems; deficiency of glucose-6-phosphate dehydrogenase; tachyarrhythmia; acute “intermittent” porphyria; form-closure glaucoma; prostatic hyperplasia (symptomatic); ileus and megacolon; collapse; pregnancy (first trimester and the last 6 weeks); lactation; child (up to 3 months or a body weight less than 5 kg).

Precautions
With caution and under medical supervision should use the drug in patients with impaired liver function or kidney problems, a tendency to arterial hypotension, asthma, individual hypersensitivity to non-steroidal anti-inflammatory drugs or non-narcotic analgesics (including “Aspirin” triad in history). Children and adolescents up to 18 years, the drug should be used only on prescription.

DOSAGE AND ADMINISTRATION
. Parenterally (intravenous, intramuscular)
Adults and adolescents over 15 years when acute severe colic is administered by slow intravenous injection of 2 ml (1 ml for 1 minute); if necessary again after 6-8 hours. For slow intravenous administration 2 ml are usually sufficient drug.
Intramuscularly injected 2 ml, 2 times a day; daily dose should not exceed 4 ml. Duration of treatment is not more than 5 days.

I took intramuscularly or intravenously administered to children according to the age and body weight following single doses:

 

Body weight / age Injection, Intravenous Injection, Intramuscular
infants 5-8 kg; 3-11 months Intravenous administration is contraindicated 0.1-0.2 ml
children 9-15 kg; 1-2 years 0.1-0.2 ml 0.2-0.3 ml
children 16-23 kg; 3-4 years 0.2-0.3 ml 0.3-0.4 ml
children 24-30 kg; 5-7 years 03, 0.4 ml 0.4-0.5 ml
children 31-45 kg; 8-12 years 0.5-0.6 ml 0.6-0.7 ml
children 46-53 kg; 12-15 years 0.8-1.0 ml 0.8-1.0 ml

If necessary, it can be assigned to the reintroduction of the drug in the same dose.
The solution was incompatible in the same syringe with other drugs.
Before the administration of injection solution should be warmed in the hand.

SIDE EFFECTS
At therapeutic doses, the drug is generally well tolerated. Sometimes allergic reactions (skin rash, itching, very rarely – anaphylactic shock, urticaria), angioedema. In rare cases – a burning sensation in the epigastric region, dry mouth, headache.
Dizziness, decreased blood pressure, tachycardia, cyanosis. Chronic administration – violations of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis (may show the following symptoms: unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of the phenomena of vaginitis or proctitis). When propensity to bronchospasm may provoke an attack.
In very rare cases – malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome). Rarely (usually with a long reception or high doses) – renal dysfunction: oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red. Very rarely – decreased sweating, paresis of accommodation, difficulty urinating.
Local reactions:. Intramuscular injection may infiltrate at the injection site
about all the side effects should be reported to your doctor.

Overdose Symptoms: vomiting, decreased blood pressure, drowsiness, confusion, nausea, epigastric pain, abnormal liver function and kidney failure, seizures. Treatment: symptomatic therapy.

INTERACTION WITH OTHER DRUGS
Concomitant use Took ® with other non-narcotic analgesics can lead to mutual reinforcement of toxic effects.
Tricyclic antidepressants, contraceptives oral, allopurinol violate metabolism testosterone enanthate side effects in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal enzymes liver weaken the effect testosterone enanthate side effects.
Concomitant use with cyclosporine reduces the level of the latter in the blood.
Sedatives and tranquilizers increase the analgesic effect testosterone enanthate side effects.
at a joint appointment with the H1-histamine blockers, butyrophenones, phenothiazines, amantadine and quinidine may be increased M-holinoliticheskogo.
When combined with ethanol -. mutual reinforcement effects
. Concomitant use with hlorpropromazinom or other phenothiazine derivatives can lead to severe hyperthermia
radiocontrast medicines and colloidal blood substitutes should not be used during treatment with drugs containing sodium testosterone enanthate side effects.
testosterone enanthate side effects, displacing connection with protein oral hypoglycemic drugs, indirect anticoagulants, steroids and indomethacin, may increase the severity of their actions.
Tiamazol cytostatics and increase the risk of leucopenia. The effect of increasing codeine, H2-histamine blockers and propranolol (slow inactivation of sodium metamizol).
Solution for injection pharmaceutically incompatible with other drugs.
If necessary, the simultaneous application of these and other medications should consult a physician.

Cautions
Do not use for the relief of acute pain in the abdomen (to determine the cause). In the period of treatment can not take alcohol; it is not recommended to drive vehicles and doing other potentially hazardous activities that require speed of physical and mental reactions.
Parenteral administration is commonly used in emergency cases and in cases where ingestion is not possible (or disturbed absorption from the gastrointestinal tract). Extreme care is required when administered 2 ml or more (the risk of a sharp decline in blood pressure). Intravenous injection should be carried out slowly, in the supine position and under the control of blood pressure, heart rate and respiratory rate. With long-term (over a week) use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.

PACKAGE
solution for intramuscular and intravenous administration; 5 ml ampoules of hydrolytic dark glass.
On 5 vials in cellular packaging made of PVC film without coating (pan).
On 1 cellular packaging (pallet), together with instructions for use in a carton box. accordo rx canada