Core: Active substance: reserpine 0.1 mg dihydroergocristine mesylate 0.58 mg (corresponding to 0.5 mg base dihydroergocristine) clopamide 5.0 mg Excipients:lactose monohydrate, povidone, stearic acid, talc (magnesium silicate), corn starch; SHELL: iron oxide red (Sikofarm red 30), titanium dioxide, peanut oil, hydrogenated, macrogol 6000, stearic acid, alcohol, cetyl, silica kolloidnsh, bezvvodny, povidone, microcrystalline cellulose, talc (magnesium hydrosilicate) sucrose.
Pharmacodynamics Brinerdin is a combination antihypertensive agent that contains in its composition three mutually supportive components. Testosterone enanthate half life – dihydrogenated ergot alkaloid blocks the alpha-adrenergic receptors causes vasodilation, reduces the total peripheral vascular resistance. The hypotensive effect of the drug exceeds the hypotensive effect of each component separately and to do any combination of the two components; onset of action – for 4-7 days, stable hypotensive effect is achieved after 1-4 weeks. Testosterone enanthate half life- sympatholytic, penetrating into the presynaptic terminals postganglionic fibers releases norepinephrine from vesicles with the simultaneous violation of its reverse transport and strengthening the process of inactivation of monoamine oxidase (MAO). It is a neurotransmitter depletion of stocks and sustained reduction in blood pressure (BP). It helps reduce the concentration in the neurons dopamine, serotonin and other neurotransmitters, exerting antipsychotic effect. It weakens the influence of sympathetic innervation of the cardiovascular system, reduces heart rate (HR) and total peripheral vascular resistance; retains activity of the parasympathetic nervous system; It deepens and strengthens the physiological sleep, inhibits reflexes interoretseptivnye. Increases motility of the gastrointestinal tract, increases the production of hydrochloric acid in the stomach superdrol buy; slows metabolic processes in the body; slows and deepens breathing movements, causes miosis, hypothermia; reduces the intensity of metabolism. It has a positive effect on lipid and protein metabolism in patients with hypertension and coronary atherosclerosis; increases renal blood flow, increases the glomerular filtration. Testosterone enanthate half life – sulfanilamide diuretic average potency, blocks the reabsorption of sodium ions at the level of the cortical segment of the loop of Henle, removes sodium, potassium, chloride and water. Brinerdin lowers blood pressure (BP) after 4-6 days initiation of therapy, and an optimal developing 1-4 weeks from start of treatment. The drug usually lasts for 14 days after completion of therapy.
Pharmacokinetics Absorption The individual components Brinerdin absorbed after oral administration as follows: reserpine about 30-40%, clopamide – about 90% and dihydroergocristine – less than 25%.Maximum plasma concentration is achieved respectively for reserpine -1-3 hours to Klopamid – about 2 hours to dihydroergocristine-about 1 hour. The distribution of individual components Brinerdin easily spread in the body (for example, dihydroergocristine volume of distribution is 52 l / kg). Communication with the plasma protein: for reserpine – does not bind, clopamide – about 46%, dihydroergocristine – about 68%. Reserpine and dihydroergocristine penetrate the blood-brain barrier and the placental. Metabolism reserpine and dihydroergocristine extensively metabolized testosterone enanthate vs cypionate in the liver to inactive metabolites.Clopamide not significantly metabolized in the liver. Elimination half-life (T 1/2 ) is long and reserpine in the first phase – 4.5 hours, and the second – about 271 hours. Path different for removing individual components: reserpine and dihydroergocristine – inactive metabolites are excreted in urine and feces, clopamide, mainly kidneys.
- hypersensitivity to any component of the drug;
- depression, Parkinson’s disease, epilepsy, concurrent electroconvulsive therapy;
- pheochromocytoma, concomitant treatment with monoamine oxidase inhibitors (MAOIs);
- gastric ulcer and duodenal ulcer exacerbation, erosive gastritis, ulcerative colitis;
- angina pectoris, recent myocardial infarction, congestive heart failure, bradycardia, atrioventricular block, intraventricular block;
- severe renal insufficiency (creatinine clearance below 30 ml / min), nephritis, uremia, nephrosclerosis;
- hypotension, pronounced cerebral atherosclerosis;
- severe liver function;
- Addison’s disease;
- hypokalemia, hyponatremia, chloropenia;
- hyperuricemia with clinical manifestations;
- angle-closure glaucoma;
- pregnancy and lactation;
- bronchial asthma;
- age of 18 years (effectiveness and safety have not been established).
Precautions: diabetes mellitus, gout, old age.
Pregnancy and lactation Since reserpine has teratogenic, Brinerdin use the drug during pregnancy is contraindicated. In addition, reserpine can cause a hazard to the fetus hypotension, bradycardia. In infants reserpine may contribute to edema, rhinorrhea, and nasal mucosa, leading to difficulty breathing and cyanosis.Klopamid can cause thrombocytopenia in the fetus. The drug is contraindicated during lactation. This is due, mainly, to the penetration into the milk and reserpine dihydroergocristine. Dihydroergocristine can cause symptoms in infants, resembling ergot poisoning, and brake / weaken lactation in mothers.
Dosing and Administration Inside, during or immediately after a meal, not liquid, squeezed small amounts of liquid. The dose is determined individually. It is recommended to start treatment with 1 tablet 1 time a day, if necessary (the absence of a satisfactory therapeutic effect), you can increase the dose to 2 times a day (every 12 hours): 1 tablet. The maximum daily dose is 2 testosterone enanthate half life. In connection with the mechanism of the drug, the possible lack of effectiveness of the drug can not talk sooner than 2 weeks after the start of the reception, so do not unnecessarily increase the initial dose in this period. in the long-term treatment in the event of a satisfactory therapeutic effect is recommended to take 1 tablet 1 time day, and in some patients the dose can be reduced to 1 1 tablet every other day. Each reduction of the dose necessary to control blood pressure.
Side effect From the digestive system: diarrhea, dry mouth, abdominal pain, nausea, vomiting, exacerbation of peptic ulcer disease, decreased appetite. Rarely – ulceration of the mucous membrane of the stomach and duodenal ulcers, gastrointestinal bleeding when used reserpine in a dose vppe 1 mg / day (the amount contained in 10 testosterone enanthate half life Brinerdin). Since the cardiovascular system: bradycardia, decreased blood pressure, cerebrovascular disorders, orthostatic hypotension, chest pain. . On the part of the central nervous system: headache, dizziness, drowsiness, weakness, anxiety, impaired concentration, insomnia, extrapyramidal disorders (tremor, stupor, Parkinson syndrome). Since the product contains reserpine, should be aware of the possibility of occurrence of depressive reactions (including tendencies to suicide) and depressive syndrome; such symptoms are rare and only in cases of large doses of reserpine (more than 1 mg / day, which corresponds to the content of reserpine in more than 10 testosterone enanthate half life Brinerdin) The respiratory system: . redness and swelling of the nasal mucosa reserpine half life of testosterone can cause symptoms of bronchospasm, but such action appears rarely and usually in patients with bronchial asthma or broncho-obstructive syndrome. Allergic reactions: skin rash, itching. On the part of hematopoiesis: thrombocytopenia with symptoms of hemorrhagic diathesis. Laboratory findings:hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, hyperuricemia , hyperglycemia, a slight increase in triglycerides, cholesterol. Other: galactorrhoea. With prolonged use at high doses – paresthesias, decreased libido, reduced potency, gynecomastia, impaired urination, accommodation spasm, conjunctival hyperemia, hypothermia, muscle weakness.
Overdosing Symptoms: nausea, vomiting, diarrhea, muscle weakness, dizziness, headache, marked reduction of blood pressure, bradycardia, arrhythmia, depression, hyporeflexia, confusion and coma. Treatment: as first aid, if the patient is conscious, induce vomiting, gastric lavage and give activated charcoal. Conduct symptomatic therapy aimed at maintaining cardiovascular function, correction of fluid and electrolyte balance.
Interactions with other drugs. Decreases effectiveness of oral hypoglycemic drugs, tricyclic antidepressants, anticoagulants. Increases in plasma concentration of lithium (slowing its excretion). Weaken the effect of antiepileptic drugs and levodopa, anticholinergics, reduce the analgesic effect of morphine. Enhances the effect of barbiturates, ethanol , drugs for inhalation anesthesia, antihistamine drugs. Enhances the effect of agonists of direct action. Barbiturates, ethanol, beta-blockers, peripheral vasodilators enhance the antihypertensive effect. Corticosteroids, non-steroidal anti-inflammatory drugs, laxatives drugs reduce the diuretic, hypotensive effects, increase the risk of hypokalemia . The treatment of MAO inhibitors -. increased inhibitory action on the central nervous system on the background of treatment with MAO inhibitors cause moderate or severe hypertension, hyperreflexia. antiarrhythmic agents – in the case of hypokalemia, which can accompany treatment, increases the risk of toxic action of amiodarone, disopyramide, quinidine; hypokalemia weakens the effect of lidocaine, mexiletine. Do not mix with dopamine (vasoconstrictive amplification reactions). In a joint application with digoxin – increase the risk of bradycardia; in the case of hypokalemia, which can accompany treatment, increased risk of intensifying adverse reactions of digoxin.
Special instructions. Since the effect Brinerdin develops relatively slowly, the dosage should not be increased more often than 1 time per week, due to the possibility of occurrence of significant decrease in blood pressure;Special care is needed in case of a joint application with other antihypertensive agents; during treatment periodically to control the level of blood pressure to determine the optimal dosing regimen. In the period of treatment may increase the level of glucose and uric acid in the serum, it is recommended to carry out periodic monitoring of these parameters, especially in patients with impaired glucose tolerance and hyperuricaemia. Required monitoring of renal function, especially in patients testosterone overdose with chronic renal failure. in the event of bradycardia during treatment, the dose should be reduced or stop the drug. During treatment requires monitoring of potassium in the blood serum. In most patients, additional drugs potassium destination is not required, provided that a diet contains sufficient potassium rich foods (fruits, vegetables, fish, cheese and low-fat, etc.). Use caution in patients with asthma and bronchospasm in case of acute need to stop taking Brinerdin. not less than 2 weeks before planned surgery, you should stop taking the drug and to replace it with another antigipertenzivnsh means. During treatment should not drink alcoholic beverages. it is appropriate to modify the dose Brinerdin in case of simultaneous use of other, interacting with them medicines. Over the 7 days before the start of electroconvulsive therapy should be discontinued Brinerdin.
Effects on ability to drive vehicles and use machines Brinerdin may interfere with the patient’s capacity for rapid responses, especially at the beginning of treatment. The treatment should not drive vehicles and to engage in any activities that require high concentration and speed of psychomotor reactions.
anabolic steroids buy online bodybuilder flexing biceps bodybuilding supplements wiki preparation h bodybuilding buying tramadol online bodybuilding and stretch marks the machine bodybuilder ” target=”_blank” style=”color:#FF1493;” href=”http://injectable-steroids.biz”>