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testosterone enanthate injection

testosterone enanthate injection

Individual hypersensitivity to the drug, chronic heart failure (decompensation stage), severe liver and kidney function, children’s age (up to 6 years).
The drug is not recommended for use during pregnancy and breastfeeding.

Dosing and Administration

Pastilles resolves in the mouth.
Adults and children over 12 years should dissolve in the mouth for 1-2 lozenges several times (up to 3 times) a day. Children from 6 to 12 years – 1 lozenge 3 times a day. The duration of the drug is determined by the severity of symptoms and duration.

Side effect

Allergic reactions (skin rash, urticaria, angioedema of the face and mucous membranes of the mouth and throat (angioedema). In this case, you need to stop taking the drug and consult a doctor.

Interaction with other drugs

Not recommended simultaneous with antitussive drugs as well as drugs testosterone enanthate injection that reduce the formation of mucus, since it is difficult expectoration attenuated sputum.

special instructions

One lozenge corresponds to 0.07 BU (bread units), which should be considered in patients with diabetes mellitus, as well as persons on a hypocaloric diet.
If you do not improve within 5 days, you should consult with your doctor.

release Form

Pastilles. 10 wafers in blisters of PVC / aluminum foil. 2 blisters with instruction on use in a cardboard box. vegetarian bodybuilding diet plan sustanon 250 organon best bodybuilding supplement

where to buy testosterone enanthate

where to buy testosterone enanthate

Where to buy testosterone enanthate of sedatives – the preparation of bromine. Like other bromides has the ability to enhance the braking process in the cerebral cortex, particularly at elevated excitability of the central nervous system. It facilitates offensive natural sleep,are readily absorbed in the gastrointestinal tract. It penetrates gistogematncheskie barriers, including placental. It is hydroxylated in the liver to oksimetabolitov which the kidneys as glucuronide.
Increased irritability, fatigue, false angina, tachycardia, labile blood pressure.
Giperchuvstvntelnost to camphor, bromide or other where to buy testosterone enanthate ingredients, liver and / or kidney failure. Children under 7 years old.
Patients with impaired hepatic function, with a history of allergic diseases.

Application of pregnancy and breast-feeding period,
during pregnancy and during breast-feeding is applied in consultation with your doctor. It is necessary to relate the benefits of the use of the mother and the risk to the fetus or child.

Dosing and Administration
Inside, after a meal. Adults and children over 14 years – 1-2 tablets 2-3 times a day; Children aged 7 to 10 years – 1 tablet 2 times a day; Children aged 10-14 years – 1 tablet 2-3 times a day. The maximum daily dose: For adults and children over 14 years – 1.5 g; for children aged 7-10 years – 0.5 g; for children aged 10-14 years – 0.75, the course of treatment – 10-15 days.

Side effects:
Allergic reactions, lethargy, drowsiness, dyspepsia.

Overdosing Symptoms: nausea, vomiting, abdominal pain, fever, anuria, delirium, muscle twitching, epileptiform convulsions, central nervous system depression, difficulty breathing, a characteristic smell of camphor breath, respiratory failure, coma. Treatment: gastric lavage, the appointment of into saline laxatives and activated charcoal inside. In convulsions where to buy testosterone enanthate use intravenous diazepam or fast barbiturates (sodium thiopental). Hemodialysis dialysate with a lipid.

Interaction with other medicines
Talk to your doctor if you are taking other medications.

Cautions Effect on performance of potentially hazardous activities that require attention and fast reactions: During treatment should abandon driving and axiolabs busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions. buying anabolic steroids test e 250 where to buy anabolic steroids

testosterone enanthate results

testosterone enanthate results

It reduces the viscosity of phlegm, activates testosterone enanthate results ciliated epithelium, increases the volume of sputum and improving its expectoration. It stimulates the production of endogenous surfactant, provides stable alveolar cells in the process of respiration. The effect is manifested after 2-5 days of starting treatment.

When administered almost completely (99%) absorbed in the gastrointestinal tract (GIT) for 30 min. Bioavailability is about 80%. Associated with the plasma protein by 99%. It penetrates testosterone enanthate results through the placental and blood-brain barriers. Penetrates into breast milk. The liver is demethylation and oxidation, is metabolized to ambroxol. The half-life is 15 hours (due to the slow diffusion of the back fabric). Excreted by the kidneys as metabolites. In chronic renal failure (CRF) is violated allocation metabolites. Repeated use can cumulate.

Indications

– Acute and chronic bronchopulmonary diseases, accompanied by the formation of increased sputum viscosity (asthma, pneumonia, bronchitis, obstructive bronchitis, bronchiectasis, emphysema, cystic fibrosis, tuberculosis, pneumoconiosis).

Contraindications

– Hypersensitivity to testosterone enanthate results and other ingredients;

– Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

– Gastric ulcer and duodenal ulcer (in the acute stage);

– Pregnancy (I term);

– Children up to age 6 years.

Carefully

– Renal and / or hepatic impairment;

– In violation of the bronchi motility, accompanied by excessive accumulation of secretions;

– A tendency to gastric bleeding in the history.

Pregnancy and lactation

Use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. Use of the drug is contraindicated during lactation.

Dosing and Administration

The drug is prescribed inside after a meal, without chewing, drinking plenty of fluids.

For adults and adolescents over 14 years : 3 times daily 1-2 tablets (24-48 mg / day).

Children 6 to 14 years, and patients with a body weight less than 50 kg : take 3 times a day 1 tablet (24 mg / day).

If the kidney function and / or liver disease should increase the interval between doses, or reduce the dose. On this issue, you should consult with your doctor.

The duration of the application is installed on an individual basis and depends on the evidence and the disease. If you want to receive more than 4-5 days is required to consult a doctor.

Side effect

Usually testosterone enanthate results 8 Berlin-Chemie is well tolerated.

In rare cases nausea, vomiting, dyspepsia, exacerbation of gastric ulcer and duodenal ulcers, allergic reactions (skin rash, rhinitis, swelling), shortness of breath, fever and chills.

Very rarely (<0.01%) – heavy anaphylactic shock.

Headache, dizziness.

The increased activity of “liver” transaminases (rare).

In all forms of allergic reactions need to stop taking the drug and inform the physician.

Overdose

Life-threatening consequences of overdose when using testosterone enanthate results 8 Berlin-Chemie, is unknown.

Possible symptoms : nausea, vomiting, diarrhea, dyspepsia.

Treatment : artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug.

Due to the high degree of protein binding and high volume distribution elimination bromgeksina hemodialysis or forced diuresis is not happening.

Interaction with other drugs

Bromhexinum not appointed concurrently with drugs that suppress the cough center (including containing codeine) because This makes it difficult to evacuate the liquefied sputum.

testosterone enanthate results facilitates the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline, ampicillin, amoxicillin) in bronchial secretion in the first 4-5 days of antimicrobial therapy.

Not compatible with alkaline solutions.

special instructions

In cases of dysmotility bronchi or with a significant amount of released sputum, use of the drug testosterone enanthate results 8 Berlin-Chemie requires caution, because of the risk of delay in the discharge of the respiratory tract.

In the course of treatment is recommended to drink plenty of fluids, which increases the effect of testosterone enanthate results sekretoliticheskoe.

In severe renal insufficiency should take into account the possibility of accumulation of metabolites in the liver.

In children, treatment should be combined with postural drainage and vibration massage of the chest, facilitating the removal of bronchial secretions.

Effect on ability to drive vehicles and management mechanisms

During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

release Form

Drops 8 mg.

On 25 pills in blisters (blister PVC / aluminum foil).

1 blister with instructions for use in a cardboard box.

enanthate testosterone

enanthate testosterone

Enanthate testosterone – a semisynthetic cephalosporin antibiotic III generation broad-spectrum.The bactericidal activity of enanthate testosterone due to suppression of the synthesis of cell membranes.Enanthate testosterone – a derivative of the basic penicillin nucleus. It is an irreversible inhibitor of beta-lactamases, which are released by microorganisms resistant to beta-lactam antibiotics; prevents degradation of penicillins and cephalosporins by the action of beta-lactamase-resistant microorganisms; binding to penicillin binding proteins, exhibits synergism when applied simultaneously with penicillins and cephalosporins.

Enanthate testosterone has no clinically significant antibacterial activity (with the exception of Neisseriaceae and Acinetobacter spp.). Sulbactam interacts with certain proteins penitsillin¬svyazyvayuschimi, so the combination of enanthate testosterone + [sulbactam] often has a more pronounced effect on the sensitive strains than one enanthate testosterone.

The combination of enanthate testosterone + [sulbactam] is active against all organisms sensitive to enanthate testosterone, and acts synergistically (reduced to 4 times the minimum inhibitory concentration (MIC) of the combination compared with enanthate testosterone).

It is active against the following microorganisms:

Gram-negative aerobes: of Acinetobacter lwoffii, of Acinetobacter anitratus *, the Aeromonas hydrophila, of Alcaligenes faecalis, of Alcaligenes odorans, of Borrelia burgdorferi, Capnocytophaga spp, Citrobacter diversus, Citrobacter freundii **, of Escherichia coli, of Enterobacter aerogenes *, of Enterobacter cloacae *, of Enterobacter spp *,.. Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae , Hafnia alvei, Klebssiella oxytoca, Klebssiella pneumoniae **, Moraxella catarrhalis, Moraxella osloensis, Moraxella spp., Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Plesiomonas shigelloides, Proteus mirabilis, Proteus vulgaris *, Proteus penneri *, Pseudomonas fluorences *, Pseudomonas spp., Providencia spp., including Providencia rettgeri *, Salmonella spp. (netifoidnye), Salmonella typhi, Serratia spp. *, including Serratia marcescens *, Shigella spp., Vibrio spp., Yersinia spp., Including Yersinia enterocolitica.

* Some isolates of these species are resistant to enanthate testosterone, mainly due to the formation of beta-lactamase, encoded chromosomes.
** Some isolates of these species are resistant to enanthate testosterone due to the formation of a number of beta-lactamase plazmidooposredovannyh.

Several strains of the above microorganisms, which are resistant to other antibiotics such as penicillins, cephalosporins, aminoglycosides, are susceptible to enanthate testosterone. Treponema pallidum is sensitive to enanthate testosterone in vitro. Clinical strains of Pseudomonas aerugenosa resistant to enanthate testosterone.

Grampopolozhitelnye aerobes: Staphylococcus aureus (including strains forming penicillinase), Staphylococcus spp. (coagulase negative), Streptococcus pyogenes (beta-hemolytic streptococci group A), Streptococcus agalactiae (beta hemolytic Streptococcus group B), Streptococcus pneumoniae, Streptococcus spp. viridians group.

Note: Methicillin-resistant Staphylococcus spp. resistant to cephalosporins, including to enanthate testosterone. Typically, Enterococcus faecalis, Enterococcus faecium and Listeria monocytogenes as stable.

Anaerobic microorganisms: of Bacteroides spp. (zhelchechuvstvitelnye) *, Clostridium spp. (except Clostridium difficile), Fusobacterium spp. (including Fusobacterium nucleatum), Peptococcus spp., Peptostreptococcus spp. * Some isolates of these species are resistant to enanthate testosterone due to the formation of beta-lactamases.

Pharmacokinetics

The maximum concentration (Cmax) after a single dose of enanthate testosterone intramuscularly (i / m) administration at a dose of 1.0 g is about 81 mg / l and is achieved 2-3 hours after administration, while it is sulbactam 6.24 mg / l and is achieved after approximately 1 hour after administration.

The area under the curve “concentration-time» (AUC) for enanthate testosterone after the / m is the same as after intravenous (i / v) administering an equivalent dose, indicating 100% bioavailability after the / m.

The volume of distribution of enanthate testosterone is 7-12 l and sulbactam – 18- 27.6 liters.

enanthate testosterone and sulbactam is well distributed in various tissues and body fluids including ascites fluid, cerebrospinal fluid (in patients with inflammation of the meninges), urine, saliva, tonsils, skin, fallopian tubes, ovaries, uterus, lungs, bones, bile, gall bladder , appendix. The drug crosses the placental barrier.

enanthate testosterone 70-90% sulbactam is 38% reversibly bound to plasma proteins.

enanthate testosterone is not metabolised systemically, and transformed into inactive metabolites by the action of intestinal microflora.

The half-life (T 1/2 ) sulbactam averages about 1 hour, enanthate testosterone – about 8 hours. The plasma clearance of enanthate testosterone – 10-20 ml / min, the renal clearance – 5-12 ml / min.

Approximately 84% of the dose of sulbactam and 50-60% of enanthate testosterone dose is excreted by the kidneys in unchanged form, the remainder of enanthate testosterone is excreted in the bile into the intestine.

Repeated use of significant changes in pharmacokinetic parameters of both components of the drug were observed. With the introduction of the drug every 8-12 hours cumulative effect was not observed.

Penetration into the cerebrospinal fluid: in infants and children with inflammation mater enanthate testosterone penetrates into cerebrospinal fluid, while in case of bacterial meningitis is an average of 17% of enanthate testosterone concentration in the plasma diffuses into the cerebrospinal fluid, which is about 4 times greater than in aseptic meningitis . After 24 hours on / in the enanthate testosterone 50-100 mg / kg body weight concentrations in the cerebrospinal fluid higher than 1.4 mg / l. In adult patients with meningitis over 2-24 hours after dosing of 50 mg / kg body weight, enanthate testosterone concentration in CSF are much greater than the minimum inhibitory concentration for the most common causes of meningitis.

Special patient groups

In newborn infants, kidneys derived about 70% of the administered dose of enanthate testosterone. The children in the first 8 days of life, as well as in persons over 75 years of T 1/2 on average 2-3 times greater than that of adults.

In patients with impaired renal or hepatic function The pharmacokinetics of enanthate testosterone changes slightly, but marked a slight increase in T 1/2 . If the function is impaired kidney excretion in the bile increases if the function is impaired liver, increases excretion by the kidneys.

In patients with varying degrees of renal impairment showed a high correlation between the total clearance of sulbactam from the body and calculated creatinine clearance. In patients with end-stage renal failure showed a significant lengthening of the T 1/2 sulbactam (up to 9.7 hours). Hemodialysis causes a significant change in half-life, total clearance and volume of distribution of sulbactam.

Indications

Infectious-inflammatory diseases caused by susceptible to the combination of enanthate testosterone with sulbactam agents:
– kidney and urinary tract infections;
– abdominal infections (peritonitis, biliary tract infections, and gastrointestinal tract);
– lower respiratory tract infections (including pneumonia);
– upper respiratory tract infections (including acute otitis media);
– bacterial meningitis;
– septicemia;
– infections of bones and joints;
– skin and soft tissue infections (including wound infections);
– disease Lyme;
– genital infections, including uncomplicated gonorrhea.
Infectious diseases in patients with reduced immunity.
Prevention of postoperative infections.

Contraindications

Hypersensitivity to enanthate testosterone and sulbactam, as well as other cephalosporins, penicillins, beta-lactam antibiotics; hyperbilirubinemia or jaundice in full-term infants; preterm infants who have not attained “alleged” age of 41 weeks (including the period of fetal development and age); full-term newborns who have shown intravenous calcium solutions; acidosis, hypoalbuminemia term infants.

Carefully

In ulcerative colitis, the human liver and kidneys, enteritis and colitis associated with the use of antibacterial drugs.

Application of pregnancy and during breastfeeding

Use of the drug during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus (enanthate testosterone and sulbactam cross the placental barrier).

If necessary, use during lactation should decide the issue of termination of breastfeeding.

Dosing and Administration

The drug is administered parenterally: intramuscularly or intravenously.

Adults and children over 12 years: the usual dose is 1-2 g of enanthate testosterone (0.5 – 1 g sulbactam) once daily or divided into two administrations (every 12 hours).

In severe cases or in infections which activators have only moderate sensitivity to enanthate testosterone, the daily dose can be increased to 4, the maximum daily dose of sulbactam is 4 g

The duration of treatment depends on the disease. As always with antibiotic therapy, administration of the drug Broadsef-C should continue for a further minimum of 48-72 hours after normalization of temperature and confirm the eradication of the pathogen. The course of treatment is usually 4-14 days; more prolonged administration may be necessary in complicated infections. The course of treatment for infections caused by Streptococcus pyogenes, must be at least 10 days.

In patients with impaired renal function there is no need to reduce the dose if liver function is normal. In chronic renal insufficiency (creatinine clearance less than 15 ml / min) – daily dose should not exceed 2 g enanthate testosterone and 1 g sulbactam.

In patients with hepatic impairment is not necessary to reduce the dose if kidney function remains normal.

When combined renal and hepatic insufficiency regularly to determine the concentration in plasma and enanthate testosterone to adjust the dose as necessary. The daily dose should not exceed 2 g enanthate testosterone without determining plasma concentrations.

Patients who are on hemodialysis, does not require the introduction of additional doses after hemodialysis, however, it is necessary to control the concentration of enanthate testosterone in plasma because of its excretion in these patients can be slow (may require dose adjustment).

Sick elderly: the usual dose for adults, with no adjustment for age.

Children under 12 years of age
Using the drug once a day is recommended to adhere to the following dosing regimens:

Infants (up to 2 weeks): 20-50 mg / kg body weight of enanthate testosterone (10-25 mg / kg sulbactam) once per day. The daily dose of enanthate testosterone should not exceed 50 mg / kg body weight.

Newborns, infants and young children (from 15 days to 12 years): the recommended daily dose of enanthate testosterone – 20-80 mg / kg (10-40 mg / kg sulbactam) once daily or divided into 2 doses (every 12 hours ).The total daily dose of enanthate testosterone in children should not exceed 2 g; sulbactam maximum daily dose should not exceed 80 mg / kg. A dose of 50 mg / kg body weight or more (enanthate testosterone) should be administered in the form of on / in infusion for 30 minutes. In the treatment of acute otitis media in children recommended once / m administering a dose of 50 mg / kg (not to exceed 1 g).

In children weighing 50 kg or more, the dose for adults.

Bacterial Meningitis
In bacterial meningitis in infants and young children, treatment begins with doses of 100 mg / kg of enanthate testosterone (but not more than 4 g) 1 time per day (50 mg / kg of sulbactam, but not more than 2 g). After identifying the pathogen and defining its sensitivity, the dose can be reduced accordingly. The best results were achieved with meningococcal meningitis while the duration of treatment of 4 days with meningitis caused by Haemophilus influenzae – 6 days, Streptococcus pneumoniae – 7 days.

Lyme disease (borreliosis): adults and children – 50 mg / kg (the highest daily dose – 2 grams) of enanthate testosterone once daily for 14 days.

Uncomplicated gonorrhea – single i / m administration of 250 mg (enanthate testosterone).

Prevention of postoperative infections, depending on the degree of risk of infection, is administered 1-2 g of enanthate testosterone (sulbactam 0.5-1 g) once per 30-90 minutes prior to surgery. In operations on the colon and rectum is well established at the same time (but separate) administration of enanthate testosterone / sulbactam and one of the drugs from the group of 5-nitroimidazoles.

Terms of preparation and administration solutions: Only fresh solution should be used.

For intramuscular administration: the contents of the vial (1.5 g) was dissolved in 3.5 ml of water for injection or a 1% lidocaine solution. After preparation, each ml containing about 250 mg calculated as enanthate testosterone.

possible to use a more diluted solution, if necessary. As with other intramuscular injection, the drug is administered in relatively large muscle; Trial aspiration helps to avoid unintentional introduction into a blood vessel. It is recommended to enter no more than 1,000 mg of enanthate testosterone (500 mg sulbactam) in a relatively large muscle. You can not enter a solution containing lidocaine intravenously.

For intravenous administration: the contents of the vial are dissolved in 10 ml of water for injection. After preparation, each ml containing about 100 mg calculated as enanthate testosterone. The solution was introduced slowly over 2-4 min.

For intravenous infusion dissolved 2 g of enanthate testosterone (1 g sulbactam) in 40 ml of one of the following solutions not containing calcium (0.9% sodium chloride, 5% or 10% dextrose, 6% dextran solution in 5% dextrose) . Solution was administered for 30 min.

Side effects

Allergic reactions: fever or chills, anaphylactic or anaphylactoid reactions (eg, bronchospasm), hives, itching, allergic dermatitis, urticaria, edema, exudative erythema multiforme, Stevens-Johnson syndrome, Lyell’s syndrome, hypersensitivity pneumonitis, serum sickness.

From the nervous system: headache, dizziness, cramps, vertigo.

From the gastrointestinal tract: abdominal pain, diarrhea, nausea, vomiting, taste disturbance, indigestion, abdominal distention, stomatitis, glossitis, pancreatitis, pseudomembranous colitis.

Disorders of the liver and biliary tract: cholelithiasis, “sludge-phenomenon” of the gallbladder, jaundice.

From the blood and lymphatic system: anemia (including hemolytic), leukopenia, lymphopenia, leukocytosis, lymphocytosis, monocytosis, neutropenia, thrombocytopenia, thrombocytosis, eosinophilia, granulocytopenia, basophils, increase (decrease) of prothrombin time, increased thromboplastin time, agranulocytosis.

Violations of the kidney and urinary: mycoses genitals, oliguria, vaginitis, nephrolithiasis.

Local reactions: with a / in the introduction – phlebitis, pain, induration along the vein; i / m administration – pain, a feeling of warmth, tightness or thickening at the injection site.

Laboratory indicators: increased activity of “liver” transaminases and alkaline phosphatase, hyperbilirubinemia, hypercreatininemia, increasing concentrations of urea, the presence of sediment in the urine, glycosuria, hematuria.

Other: increased sweating, “tides” of blood, nosebleeds, palpitations, formation of precipitates in the lungs.

Overdose

Symptoms: neurological disorders, including seizures.

Treatment: Treatment of symptomatic overdose. No specific antidote.

With an overdose of hemodialysis and peritoneal dialysis does not reduce the concentration of enanthate testosterone.

Interaction with other drugs

Bacteriostatic antibiotics reduce the bactericidal effect of enanthate testosterone / sulbactam.

Chloramphenicol antagonism in vitro.

Pharmaceutical interaction

A solution of enanthate testosterone / sulbactam should not be mixed or administered simultaneously with other antimicrobials. Pharmaceutically compatible with solutions containing calcium ions (including Ringer’s solution and Hartmann) – may form precipitates; as well as with amsacrine, vancomycin, fluconazole and aminoglycosides.

enanthate testosterone does not contain N-metiltiotetrazolnoy group, so simultaneous use of ethanol does not cause reactions disulfiramopodobnyh inherent in some cephalosporins.

With simultaneous use of large doses of enanthate testosterone and “loop” diuretics (eg, furosemide), renal dysfunction was observed. Instructions that enanthate testosterone increases renal toxicity of aminoglycosides, no.Probenecid does not affect the excretion of enanthate testosterone.

enanthate testosterone and aminoglycosides have synergistic against many gram-negative bacteria. Despite the fact that the increased efficiency of such combinations are not always predictable, it should be borne in mind when severe, life-threatening infections such as caused by Pseudomonas aeruginosa.

enanthate testosterone reduces the effectiveness of oral contraceptives, so it is recommended to use additional non-hormonal contraceptives.

The formation of calcium salt of enanthate testosterone precipitates can occur by mixing the drug and calcium solutions using a venous access. Do not use the drug simultaneously with calcium-containing solutions for the on / in the introduction, including continuous infusion of calcium-containing solutions, such as parenteral nutrition using a Y-connector. For all patient groups except infants may sequential administration of the drug and calcium solutions by carefully washing the infusion systems between injections compatible liquid.

special instructions

Patients treated with beta-lactam antibiotics such as cephalosporins, cases of serious hypersensitivity reactions (anaphylactic) are described. The risk of hypersensitivity reactions, including those leading to death, higher in patients with a history of hypersensitivity reactions were observed many allergens. If you have an allergic reaction, you must stop the drug and prescribe appropriate therapy.

In severe anaphylactic reactions must be urgent administration of epinephrine. Intravenously administered corticosteroids and ensure the airway, including intubation.

With simultaneous use of aminoglycosides is necessary to monitor renal function. When concomitant severe renal and hepatic failure, as well as in patients on hemodialysis, should be regularly to determine the concentration of drug in plasma.

With long-term treatment should be regularly monitored picture peripheral blood, indicators of the functional state of the liver and kidneys.

In rare cases, the gallbladder marked darkening (precipitates the calcium salt of enanthate testosterone) by ultrasound (US), which disappear after cessation of treatment. With the development of symptoms or signs indicating a possible gallbladder disease, or in the presence of ultrasound signs “sludge-phenomenon” should stop administering the drug.

In applying the drug described rare cases of pancreatitis that developed, probably due to biliary obstruction. The majority of patients had risk factors of stagnation in the biliary tract (previous therapy drug, severe comorbidities, total parenteral nutrition); at the same time we can not exclude the role of education launcher precipitates in the biliary tract under the influence of enanthate testosterone.

When using enanthate testosterone described rare cases of changes in prothrombin time. Patients with vitamin K deficiency (impaired synthesis, malnutrition) may require monitoring of prothrombin time and purpose of vitamin K (10 m g / week) with an increase in prothrombin time prior to or during therapy.

There are cases of fatal reactions as a result of deposition of enanthate testosterone-calcium precipitates in the lungs and kidneys of neonates. Theoretically, there is the possibility of interaction with calcium-enanthate testosterone solutions for the on / in and among patients in other age groups, enanthate testosterone should therefore not be mixed with calcium-containing solutions (including those for parenteral nutrition) and administered simultaneously, including via separate approaches for infusion at different locations. Theoretically, based on the rate of 5 T 1/2 enanthate testosterone interval between administration of enanthate testosterone and calcium-containing solutions must not be less than 48 hours. The data on the possible interaction of enanthate testosterone with calcium-containing oral medications, as well as enanthate testosterone for the / m of a calcium-containing drugs (I / O and oral) are absent.

In the treatment with enanthate testosterone can be marked false positive Coombs test, tests for galactosemia, the determination of glucose in the urine (glucosuria is recommended to determine only the enzyme method).

In applying the drug, in patients receiving both and 2-3 weeks. after discontinuation of treatment may develop diarrhea caused by Clostridium difficile (pseudomembranous colitis). In mild cases enough to discontinuation of treatment and the use of ion exchange resins (cholestyramine, colestipol), in severe cases, it shows compensation of fluid loss, electrolytes and protein, the appointment of vancomycin and metronidazole inside. Do not use drugs, inhibiting intestinal peristalsis.

When using enanthate testosterone (as well as other antibiotics) may develop superinfection, which requires discontinuation of the drug and appropriate treatment.

enanthate testosterone can displace bilirubin from its association with serum albumin.

As with other cephalosporins, the treatment of the drug may develop autoimmune hemolytic anemia. Cases of severe hemolytic anemia in adults and children, including those with a fatal outcome. In case of anemia drug therapy should be discontinued.

Effects on ability to drive vehicles and mechanisms

Given the profile of adverse reactions during treatment must be careful when driving, operating machinery and other classes of potentially hazardous activities that require increased attention and psychomotor speed reactions. Trenbolone Enanthate for sale

testosterone enanthate half life

testosterone enanthate half life

Core: Active substance: reserpine 0.1 mg dihydroergocristine mesylate 0.58 mg (corresponding to 0.5 mg base dihydroergocristine) clopamide 5.0 mg Excipients:lactose monohydrate, povidone, stearic acid, talc (magnesium silicate), corn starch; SHELL: iron oxide red (Sikofarm red 30), titanium dioxide, peanut oil, hydrogenated, macrogol 6000, stearic acid, alcohol, cetyl, silica kolloidnsh, bezvvodny, povidone, microcrystalline cellulose, talc (magnesium hydrosilicate) sucrose.

Pharmacodynamics Brinerdin is a combination antihypertensive agent that contains in its composition three mutually supportive components. Testosterone enanthate half life – dihydrogenated ergot alkaloid blocks the alpha-adrenergic receptors causes vasodilation, reduces the total peripheral vascular resistance. The hypotensive effect of the drug exceeds the hypotensive effect of each component separately and to do any combination of the two components; onset of action – for 4-7 days, stable hypotensive effect is achieved after 1-4 weeks. Testosterone enanthate half life- sympatholytic, penetrating into the presynaptic terminals postganglionic fibers releases norepinephrine from vesicles with the simultaneous violation of its reverse transport and strengthening the process of inactivation of monoamine oxidase (MAO). It is a neurotransmitter depletion of stocks and sustained reduction in blood pressure (BP). It helps reduce the concentration in the neurons dopamine, serotonin and other neurotransmitters, exerting antipsychotic effect. It weakens the influence of sympathetic innervation of the cardiovascular system, reduces heart rate (HR) and total peripheral vascular resistance; retains activity of the parasympathetic nervous system; It deepens and strengthens the physiological sleep, inhibits reflexes interoretseptivnye. Increases motility of the gastrointestinal tract, increases the production of hydrochloric acid in the stomach superdrol buy; slows metabolic processes in the body; slows and deepens breathing movements, causes miosis, hypothermia; reduces the intensity of metabolism. It has a positive effect on lipid and protein metabolism in patients with hypertension and coronary atherosclerosis; increases renal blood flow, increases the glomerular filtration. Testosterone enanthate half life – sulfanilamide diuretic average potency, blocks the reabsorption of sodium ions at the level of the cortical segment of the loop of Henle, removes sodium, potassium, chloride and water. Brinerdin lowers blood pressure (BP) after 4-6 days initiation of therapy, and an optimal developing 1-4 weeks from start of treatment. The drug usually lasts for 14 days after completion of therapy.

Pharmacokinetics Absorption The individual components Brinerdin absorbed after oral administration as follows: reserpine about 30-40%, clopamide – about 90% and dihydroergocristine – less than 25%.Maximum plasma concentration is achieved respectively for reserpine -1-3 hours to Klopamid – about 2 hours to dihydroergocristine-about 1 hour. The distribution of individual components Brinerdin easily spread in the body (for example, dihydroergocristine volume of distribution is 52 l / kg). Communication with the plasma protein: for reserpine – does not bind, clopamide – about 46%, dihydroergocristine – about 68%. Reserpine and dihydroergocristine penetrate the blood-brain barrier and the placental. Metabolism reserpine and dihydroergocristine extensively metabolized in the liver to inactive metabolites.Clopamide not significantly metabolized in the liver. Elimination half-life (T 1/2 ) is long and reserpine in the first phase – 4.5 hours, and the second – about 271 hours. Path different for removing individual components: reserpine and dihydroergocristine – inactive metabolites are excreted in urine and feces, clopamide, mainly kidneys.

Indications

Hypertension.

Contraindications

  • hypersensitivity to any component of the drug;
  • depression, Parkinson’s disease, epilepsy, concurrent electroconvulsive therapy;
  • pheochromocytoma, concomitant treatment with monoamine oxidase inhibitors (MAOIs);
  • gastric ulcer and duodenal ulcer exacerbation, erosive gastritis, ulcerative colitis;
  • angina pectoris, recent myocardial infarction, congestive heart failure, bradycardia, atrioventricular block, intraventricular block;
  • severe renal insufficiency (creatinine clearance below 30 ml / min), nephritis, uremia, nephrosclerosis;
  • hypotension, pronounced cerebral atherosclerosis;
  • severe liver function;
  • Addison’s disease;
  • hypokalemia, hyponatremia, chloropenia;
  • hyperuricemia with clinical manifestations;
  • angle-closure glaucoma;
  • hemodyscrasia;
  • pregnancy and lactation;
  • bronchial asthma;
  • age of 18 years (effectiveness and safety have not been established).

Precautions: diabetes mellitus, gout, old age.

Pregnancy and lactation
Since reserpine has teratogenic, Brinerdin use the drug during pregnancy is contraindicated.
In addition, reserpine can cause a hazard to the fetus hypotension, bradycardia. In infants reserpine may contribute to edema, rhinorrhea, and nasal mucosa, leading to difficulty breathing and cyanosis.Klopamid can cause thrombocytopenia in the fetus.
The drug is contraindicated during lactation. This is due, mainly, to the penetration into the milk and reserpine dihydroergocristine.
Dihydroergocristine can cause symptoms in infants, resembling ergot poisoning, and brake / weaken lactation in mothers.

Dosing and Administration
Inside, during or immediately after a meal, not liquid, squeezed small amounts of liquid.
The dose is determined individually. It is recommended to start treatment with 1 tablet 1 time a day, if necessary (the absence of a satisfactory therapeutic effect), you can increase the dose to 2 times a day (every 12 hours): 1 tablet.
The maximum daily dose is 2 testosterone enanthate half life.
In connection with the mechanism of the drug, the possible lack of effectiveness of the drug can not talk sooner than 2 weeks after the start of the reception, so do not unnecessarily increase the initial dose in this period.
in the long-term treatment in the event of a satisfactory therapeutic effect is recommended to take 1 tablet 1 time day, and in some patients the dose can be reduced to 1 1 tablet every other day. Each reduction of the dose necessary to control blood pressure.

Side effect From the digestive system: diarrhea, dry mouth, abdominal pain, nausea, vomiting, exacerbation of peptic ulcer disease, decreased appetite. Rarely – ulceration of the mucous membrane of the stomach and duodenal ulcers, gastrointestinal bleeding when used reserpine in a dose vppe 1 mg / day (the amount contained in 10 testosterone enanthate half life Brinerdin). Since the cardiovascular system: bradycardia, decreased blood pressure, cerebrovascular disorders, orthostatic hypotension, chest pain. . On the part of the central nervous system: headache, dizziness, drowsiness, weakness, anxiety, impaired concentration, insomnia, extrapyramidal disorders (tremor, stupor, Parkinson syndrome). Since the product contains reserpine, should be aware of the possibility of occurrence of depressive reactions (including tendencies to suicide) and depressive syndrome; such symptoms are rare and only in cases of large doses of reserpine (more than 1 mg / day, which corresponds to the content of reserpine in more than 10 testosterone enanthate half life Brinerdin) The respiratory system: . redness and swelling of the nasal mucosa reserpine can cause symptoms of bronchospasm, but such action appears rarely and usually in patients with bronchial asthma or broncho-obstructive syndrome. Allergic reactions: skin rash, itching. On the part of hematopoiesis: thrombocytopenia with symptoms of hemorrhagic diathesis. Laboratory findings:hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, hyperuricemia , hyperglycemia, a slight increase in triglycerides, cholesterol. Other: galactorrhoea. With prolonged use at high doses – paresthesias, decreased libido, reduced potency, gynecomastia, impaired urination, accommodation spasm, conjunctival hyperemia, hypothermia, muscle weakness.

Overdosing
Symptoms: nausea, vomiting, diarrhea, muscle weakness, dizziness, headache, marked reduction of blood pressure, bradycardia, arrhythmia, depression, hyporeflexia, confusion and coma.
Treatment: as first aid, if the patient is conscious, induce vomiting, gastric lavage and give activated charcoal. Conduct symptomatic therapy aimed at maintaining cardiovascular function, correction of fluid and electrolyte balance.

Interactions with other drugs.
Decreases effectiveness of oral hypoglycemic drugs, tricyclic antidepressants, anticoagulants.
Increases in plasma concentration of lithium (slowing its excretion).
Weaken the effect of antiepileptic drugs and levodopa, anticholinergics, reduce the analgesic effect of morphine.
Enhances the effect of barbiturates, ethanol , drugs for inhalation anesthesia, antihistamine drugs.
Enhances the effect of agonists of direct action.
Barbiturates, ethanol, beta-blockers, peripheral vasodilators enhance the antihypertensive effect.
Corticosteroids, non-steroidal anti-inflammatory drugs, laxatives drugs reduce the diuretic, hypotensive effects, increase the risk of hypokalemia .
The treatment of MAO inhibitors -. increased inhibitory action on the central nervous system
on the background of treatment with MAO inhibitors cause moderate or severe hypertension, hyperreflexia.
antiarrhythmic agents – in the case of hypokalemia, which can accompany treatment, increases the risk of toxic action of amiodarone, disopyramide, quinidine; hypokalemia weakens the effect of lidocaine, mexiletine.
Do not mix with dopamine (vasoconstrictive amplification reactions).
In a joint application with digoxin – increase the risk of bradycardia; in the case of hypokalemia, which can accompany treatment, increased risk of intensifying adverse reactions of digoxin.

Special instructions.
Since the effect Brinerdin develops relatively slowly, the dosage should not be increased more often than 1 time per week, due to the possibility of occurrence of significant decrease in blood pressure;Special care is needed in case of a joint application with other antihypertensive agents; during treatment periodically to control the level of blood pressure to determine the optimal dosing regimen.
In the period of treatment may increase the level of glucose and uric acid in the serum, it is recommended to carry out periodic monitoring of these parameters, especially in patients with impaired glucose tolerance and hyperuricaemia.
Required monitoring of renal function, especially in patients with chronic renal failure.
in the event of bradycardia during treatment, the dose should be reduced or stop the drug.
During treatment requires monitoring of potassium in the blood serum. In most patients, additional drugs potassium destination is not required, provided that a diet contains sufficient potassium rich foods (fruits, vegetables, fish, cheese and low-fat, etc.).
Use caution in patients with asthma and bronchospasm in case of acute need to stop taking Brinerdin.
not less than 2 weeks before planned surgery, you should stop taking the drug and to replace it with another antigipertenzivnsh means.
During treatment should not drink alcoholic beverages.
it is appropriate to modify the dose Brinerdin in case of simultaneous use of other, interacting with them medicines.
Over the 7 days before the start of electroconvulsive therapy should be discontinued Brinerdin.

Effects on ability to drive vehicles and use machines
Brinerdin may interfere with the patient’s capacity for rapid responses, especially at the beginning of treatment. The treatment should not drive vehicles and to engage in any activities that require high concentration and speed of psychomotor reactions.

The release form
: 10 testosterone enanthate half life in blister. 2 blisters with instruction on use is placed in a cardboard box. online anabolic steroids pharmacy

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